American college student Alex (Josh Duhamel), his younger teenage sister Bea (Olivia Wilde) along with their close friend Amy (Beau Garrett) are backpacking through Brazil. They meet up with similar companions: wild and crazy British mates Finn (Desmons Askew) and Liam (Max Brown), together with Australian traveler Pru (Melissa George), on a cross country bus. They barely survive after it crashes off a cliff. Further mishaps occur due to becoming stranded on a beach by so-called "friendly locals", some of whom have deprived them of all their processions! Searching for any sympathetic police, they meet familiar face Kiko (Agels Steib), who offers to lead them to sanctuary that being a house deep in the jungle. But upon finally reaching this supposed safe haven Amy soon vanishes, and it is only then that they discover (way too late) that their "saviors" offering them shelter are operators of a black market specializing in running human organs, who are seeking unwilling foreign donors (foreign tourist) to benefit their unfortunate countrymen. In their captors' eyes, foreigners have come into Brazil, raping their precious lands of its rubber, sugar, gold—even using its people as throwaway sexual playthings. For this exploitation of their country, our backpackers are now set to go under the surgeon's scalpel, courtesy of the captors twisted ringleader Dr. Zamora (Miguel Lunardi); Brazil's answer to 'Dr. Giggles'.