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In 2046, in a research facility in Mars, some subjects are released and the place is kept in quarantine. A team of Marines, leaded by Sarge (The Rock), is assigned to rescue the personnel and retrieve the research data, with the support of Dr. Samantha Grimm (Rosamund Pike), the twin sister of the Marine John "Reaper" Grimm (Karl Urban). While in the mission, Samantha finds a dark hidden secret about the monsters and the researches.