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After her divorce, Meg Altman and her daughter Sarah move into an old-fashioned house with one very modern addition: a "panic room" which is virtually impossible to break into, designed for refuge during a home invasion. In their first night in the house a trio of thieves do break in and Meg and Sarah rush into the panic room. However, the intruders are looking for something inside the panic room, and given the recent move the room's hotline to the police hasn't been hooked up yet. Worse, Sarah is diabetic and the room doesn't contain any sugar...