'Go' is set mostly during one long Christmas Eve in the lives of a group of young adults on the events surrounding a drug deal in Los Angeles replayed three different times from three different views. In a straightforward manner; when slacker Simon Baines (Desmond Asknew) takes off for a getaway to Las Vegas with his friends, Ronna (Sarah Polley) takes his shift at the 24-hour grocery store where they work. When two guys, named Adam and Zack (Scott Wolf and Jay Mohr), walk in asking to score some dope from Simon, Ronna takes it upon herself and her friends Claire (Katie Holmes) and Mannie (Nathan Bexton) to buy some some stuff from the local drug dealer Todd Gains (Timothy Olyphant). But the drug deal is a sting that Adam and Zack are forced to set up by an overzealous narcotics agent, Burke (William Fichtner). Ronna is forced to dispose of the drugs. With no other alternative, she tries to double-cross Todd with phony drugs. Meanwhile in Las Vegas, Simon's adventures with his best friend Marcus (Taye Diggs) hit an unfortunate turn during a trip to a strip club, while Adam and Zack end up spending Christmas Eve with Burke and his wife Irene (Jane Krakowski), and afterwards while driving to a rave that Ronna is dealing, the guys accidentally hit Ronna with their car and leave her for dead. Nearby, Mannie nearly OD's on dope, and Claire gets more friendly with a vengeful Todd whom is now looking for Ronna.